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Pharmacogenomic Testing (PGx)

Findings from pharmacogenomics research can lead to improved outcomes for both individuals and healthcare providers through improved medication safety, efficacy and lowered medical costs. 

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Benefits and Use

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PGx testing is the study of how your body responds to medications. Specifically, PGx examines variants of genes that are involved with drug metabolism and transport, and medication targets. This relatively new field combines pharmacology and genomics to develop effective, safe medications and doses that will be tailored to a person’s genetic makeup.

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Do you have patients on 4 or more medications? 

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Could one of your patients have an adverse drug reaction to a medication you prescribed?

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Do you have patients on antidepressants, stimulants, statins, or Plavix?  

If the answer to one or more of the above is affirmative, then PGx could benefit you and your patients.

PGx testing can be applied to individuals of any age.  PGx can determine which medications may cause an adverse drug reaction (ADR). Perhaps the individual is a poor metabolizer which can lead to toxic build up of a medication.  Alternatively, a patient may have an underwhelming response to a normal dose of a medication if he or she is an ultra-rapid metabolizer.  Here PGx can guide treatment and provide rationale for higher than normal dosage of medication.  PGx determines both "poor" and "ultra-rapid" metabolizers and those in between.

Considering clinical utility for all ages but especially children is warranted since their physical growth and development impacts drug absorption, transportation, and excretion.  However, the American Academy of Pediatrics states, "When performed for therapeutic purposes, pharmacogenetic testing of children is acceptable, with permission of parents or guardians and, when appropriate, the child’s assent."   Although most visits to the Emergency Department for adverse drug reactions in children are primarily due to overdoses (45%),13% were due to adverse effects of drugs (see linked article). Because children and adolescents may have greater risk of ADR from psychotropic medications as compared to adults, PGx testing can be beneficial to start the patient on the right drug at the right dose with the right frequency in order to avoid an ADR.  PGx testing in children and adolescents is beneficial not only when an adverse drug reaction has occurred but prior to the initiation of anxiolytics, antidepressants, and stimulants in order to prescribe the right and effective dose the first time - avoiding the often wasteful and potentially harmful titration period. Avoidance of an ADR is always beneficial regardless of a patient's age. PGx not only can pinpoint the culprit medication of an ADR but which medications have potential to cause an ADR in the future.  PGx guides the medical practitioner to initiate the right drug, at the right dose for a therapeutic effect the first time. As a result PGx truly allows healthcare providers to offer personalized medicine.

Pediatric Considerations​

Through PGx Healthcare Providers Can:

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©2021 by RevMed Group.

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